Alimentiv | Protocol RCT-01741 (PATHFINDER) - Currently Recruiting
To compare available biologic classes as first-line treatment for achieving 1-year corticosteroid-free endoscopic remission in adult participants with moderate-to-severely active ileal or ileocolonic Crohn’s disease
Study Title:
A Pragmatic, Active-comparator, Parallel-group, Randomized Trial to Evaluate the Optimal First-line Treatment Strategy for Moderate-to-Severely Active Ileal-dominant Crohn’s Disease
Janssen | Protocol CNTO1959CRD3005 (FUZION) - Currently Recruiting
Molecule: Guselkumab for Fistulizing Crohn's Disease (Anti-Il23p19)
Study title:
A phase 3, randomized, placebo-controlled, parallel-group, multicenter study to evaluate the efficacy and safety of guselkumab in participants with fistulizing, perianal Crohn’s Disease
Beth Israel Medical Center & Alimentiv | Protocol RCT01437 (OPTIMIZE Trial) - Currently Recruiting
Molecule: N/A
Study title:
Proactive infliximab optimization using a pharmacokinetic dashboard versus standard of care in patients with Crohn’s disease: The OPTIMIZE Trial
Arena | Protocol APD334-202 (CULTIVATE) - Recruitment on Hold
Molecule: Etrasimod (orally administered, selective, synthetic sphingosine 1-phosphate (S1P) receptor 1, 4, 5 modulator)
Study Title:
A Phase 2b, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Assess the Efficacy and Safety of Oral Etrasimod as Induction Therapy in Subjects With Moderately to Severely Active Crohn’s Disease.
Merck | Protocol MK-7240-008 - Pending approbation
Molecule: Tulisokibart for Active Crohn's Disease
Study title:
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Program to Evaluate the Efficacy and Safety of Tulisokibart in Participants with Moderately to Severely Active Crohn’s Disease
TAKEDA | Protocol TAK-279-CD-2001 - Pending approbation
Molecule: Oral TAK-279 for Moderately to Severely Active Crohn’s Disease
Study title:
A Phase 2b, Multicenter, Randomized, Double-Blind Induction, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of Oral TAK-279 in Subjects with Moderately to Severely Active Crohn’s Disease
A Phase 2b Study to Evaluate the Efficacy and Safety of Oral TAK-279 in Subjects with Moderately to Severely Active Crohn’s Disease
AbbVie | Protocol P23-899 (UPlift) - Pending approbation
Molecule: Upadacitinib (Rinvoq) for Moderate to Severe Crohn's Disease
Study title:
A multi-country, prospective, post-marketing study of UPadacitinib evaluating speed of onset and durability of effectiveness for patients with moderate to severe Crohn’s disease for 3 years in real-world clinical practice